One of the most straightforward use cases of Handshake names is to set up a website on them. You can also use Handshake names in these other ways.
Vercel offers many templates that you can use to build your website, hosted on Vercel.
Host any HTML file on your Handshake name through Github Pages. The template used in the video can be accessed at templates.nb/.
Skyinclude.com Mike made a quick video on how to build a Handshake site using Wordpress.org, WP2Static.com, and Amazon AWS.amazon.com with Namebase.io as the TLD registrar.
In this tutorial @kiba_gateaux does a quick run through of how to deploy a site to github pages and access it with a Handshake domain name. In just 10 minutes you can have a website at your own personal TLD!